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Biodistribution studies

Preclinical and clinical phase I, II, III or IV studies generally check different parameters of drugs.
The use of vectors for gene therapy requires an evaluation of the biodistribution of viruses in the body.

Texcell has developed accurate protocols to detect vectors or specific gene sequences in different samples: blood, urine, nasopharyngeal swabs, faeces and organs (lung, liver, heart, muscle etc.).
Texcell uses highly sensitive and specific methods to extract DNA from these samples. After extraction, specific vector and/or transgene DNA sequences are detected by using real-time quantitative PCR (RTQ-PCR).

Due to our vast experience in biodistribution studies, we are aware of the case by case nature of these analyses. So, please feel free to contact us directly to discuss about your pre-clinical or clinical phase I, II, III studies so that we can propose a state-of-the-art protocol that meets your specific requirements:

Vectors that have already been evaluated:
Samples tested:
Sample origins:
  • Adenoviruses
  • Retroviruses
  • Vaccines
  • Plasmids
  • Lentivirus
  • Blood
  • Urine
  • Nasopharyngal swabs
  • Feces
  • Large panel of different organs
  • Rat
  • Mouse
  • Monkey
  • Human

 

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